Cyclohexyl 2-naphthyl

R = Ph. 4-MePh, 2-MePh, 4-MeOPh, 1-naphthyl, 2-thienyl, cyclohexyl... 

R = isomenthyl 2-(a-naphthyl)cyclohexyl 8-phenylmenthyl 8-(/J-naphthyl)menthyl 8-(3,5-dimethylphenyl)menthyl. 

The reaction of -ATPa.se with N-cyclohexyl-N -(4-dimethyl-amino-a-naphthyl)carbodiimide (NCD-4)... 

Abbreviations EPR, electron paramagnetic resonance FITC, fluorescein-5 -isothiocyanate lAEDANS, iV-iodoacetyl-N -(5-sulfo-l-naphthyl)ethylenediamine NCD, fluorescent yV-cyclohexyl-N -(4-dimethyl-amino-a-naphthyl)carbodiimide RITC, rhodamine-5 -isothiocyanate DPPE, dipalmitoylphosphatidyl-ethanolamine PE, egg phosphatidyl-ethanolamine ANS, 8-anilino-l-naphthalene sulfonate DPH, diphenylhexatriene e-ADP, l,iV -ethanoadenosine-5 -diphosphate TNP-ADP, 2 [3 ]-0-(2,4,6-trinitrophe-nyl)adenosine-5 -diphosphate. 

The /rau.v-2-naphthyl cyclohexyl sulfone 15 can be prepared readily in either enantiomeric form. The corresponding ester enolates can be alkylated in good yield and diastereoselectivity.98 In this case, the steric shielding is provided by the naphthyl... 

Ar = Ph, 3-CF3Ph, 2-MeOPh, 4-MeOPh, 3-pyridyl, 1-cyclohexyl, 1-naphthyl... 

Ar= Ph and (methyl, alkoxy, halo, nitro) derivatives, 3-pyridyl, 1-naphthyl, 4-cyclohexenyl, cyclohexyl (55-94 %)... 

Conducted in toluene. BHA = 2,6-di-ter -butyl-4-methoxyphenyl Naph = naphthyl Cy = cyclohexyl Ar = 2,6-diisopropylphenyl ent = enantio. Molar equivalents to the amounts of organolithium. 

A -stacking interaction (cf. equation 39) between the naphthyl and vinyl zinc moieties is crucial in order to obtain high diastereoselection. If naphthyl is substituted by phenyl, the dr drops to 80/20 and is completely lost with cyclohexyl. 

Reaction of silicon tetrafluoride with phenylmagnesium bromide at 0 C in diethyl ether provides fluorotriphenylsilane and fluorodiphenylsilane in 59.5 and 5% yield, respectively.3 Chloro(cy-clohexyl)(l-naphthyl)silane is converted into (cyclohexyl)fluoro(l-naphthyl)silane by reaction with a reagent which is prepared by bubbling silicon tetrafluoride through a mixture of tet-rahydrofuran and water.12... 

Ethyl, methyl > m-tolyl, phenyl >/>-tolyl, p-ethoxyphenyl, p-methoxy-phenyl, o-tolyl, o-ethoxyphenyl, o-methoxyphenyl > cyclohexyl, mesityl, 1-naphthyl. The reaction is catalyzed by metal salts such as aluminum chloride. 

FIGURE 10.14 Hybrid model of the TS for hydrogenation of acetophenone by Ru(BINAP) (cyclohexanediamine)H2 (see Section 10.4.3). The central Ru(PH3)2(NH3)2H2 + CH20 system (shown in ball-and-stick format) is treated at a high level of theory, with the phenyl, naphthyl, methyl, and cyclohexyl groups (stick format) treated at a lower level. 

We probed the reactivity of the carboxylates using a fluorescent carboxylate-selective chemical dye, N-cyclohexyl-N -(4-(dimethylamino)naphthyl)carbodiimide (NCD4). Using UV-visible spectroscopy, native gel electrophoresis, and denaturing gel electrophoresis, covalent modification with the dye was confirmed (Figure 9.5). The latter showed that the dye was attached to both the S and the L subunit, an expected observation, as the structural data suggested carboxylates on both subunits. A quantification of the number of bound dye molecules could not be achieved owing to the instability of the dye in aqueous solvent a reliable extinction coefficient could not be determined. 

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