Cyclohexene-3-one

Cyclohexen-1-one (97%) was purchased from Aldrich Chemical Company, Inc. Caution This chemical is highly toxic glove protection is recommended. 

Acetylacetonylbenzoic acid, 58, 55, 56 2-Acetyl-l,3-cyclohexadien-l-ol, 59, 62 Acetylcyclohexane, 55, 25 2-Acetylcyclohexanone, 59, 59 2-ACETYL-2-CYCLOHEXEN-1-ONE, 59,... 

B. 2-(4-Methoxyphenyl)-2-cyclohexen-1-one. A 500-mL, round-bottomed flask, equipped with a 1.5-in. Teflon-coated magnetic stirring bar and an argon inlet adaptor, is charged with 10.02 g (45.1 mmol) of 2-iodo-2-cyclohexen-1-one, 10.69 g (70.4 mmol, 1.56 eq) of 4-methoxyphenylboronic acid (Note 8), 16.72 g (72.1 mmol, 1.6 eq) of silver(l) oxide (Ag20) (Note 9), 0.85 g (2.8 mmol, 6 mol %) of triphenylarsine (Note 10), 0.53 g (1.4 mmol, 3 mol %) of palladium(ll) bis(benzonitrile)dichloride (Note 11), 200 mL of tetrahydrofuran (THF) and 25 mL of water (Note 12). The reaction mixture, flushed with argon, is stirred for 1 hr and then quenched by the addition of 125 mL of saturated aqueous ammonium chloride. After the solution is stirred for 1 hr, the... 

Cyanocyclohexene 2-Cyclohexen-1 -one Allyl acetate Stilbene Styrene... 

Rabbits and rats treated orally with isophorone excreted unchanged isophorone in the expired air and in the urine (Dutertre-Catella et al. 1978 Truhaut et al. 1970). The urine also contained 3-carboxy-5, 5-dimethyl-2-cyclohexene-1-one and glucuronic conjugates of... 

Furthermore, analytical methods for the detection of isophorone or its metabolites in humans tissues and fluids were not located. Metabolism studies in rats and rabbits, however, indicated that isophorone, isophorol, dihydroisophorone, 3-carboxy-5,5-dimethyl-2-cyclohexene-1-one, and cis- and... 

Dutertre-Catella CH, Nguyen PL, Dang Quoc Q, Truhaut R. 1978. Metabolic transformations of the 3,5,5-2-cyclohexene-1-one trimethyl (isophorone). Toxicol Eur Res 1(4) 209-216. 

SYNTHESIS OF 3-ETH0XY-6-IETHYL-2-CYCL0HEXEN-1-0NE 2-Cyclohexen-1-one, 3-ethoxy-6-nethy 1-)... 

E-l,2-Dichlorovi nyl)-3-ethoxy-6-methy1-2-cyclohexen-1-one 2-Cyclohexen-l-one, 6-(l,2-dichloroethenyl)-3-ethoxy-6-methyl- (10) (73843-25-1) Diisobutylaluminum hydride Aluminum, hydrodiisohutyl- (8) Aluminum, hydro-bis(2-methylpropyl)- (9) (1191-15-7)... 

Cycloaddition of 1-Dimethylamino-3-siloxy-1,3-butadiene with Methyl Acrylate Application to the Synthesis of 4-Hydroxyethyl-2-cyclohexen-1-one. 

Methyl-2-cyclohexen-1-one can be purchased from the Aldrich Chemical Company, Inc. or prepared according to a known procedure.2 Checkers obtained material from Aldrich Chemical Company, Inc. and Lancaster Synthesis, Inc. 

METHOXYCARBONYL-1,1,6-TRIMETHYL-1,4,4a,5,6,7,8,8a-OCTAHYDRO-2,3-BENZOPYRONE, an intramolecular Diels-Alder reaction is responsible for the diastereoselectivity. The stereoselective 1,4-functionalization of 1,3-dienes is exemplified by a two-step process leading to cis- and trans-1-ACETOXY-4-(DICARBOMETHOXYMETHYL)-2-CYCLOHEXENE. The effectiveness of a silyl hydride in providing a means for erythro-directed reduction of a p-keto amide is applied in a route to ERYTHRO-1 -(3-HYDROXY-2-METHYL-3-PHENYL-PROPANOYLJPIPERIDINE. This is followed by an asymmetric synthesis based on a chiral bicyclic lactam leading to (R)-4-ETHYL-4-ALLYL-2-CYCLOHEXEN-1-ONE. The stereoselectivity with which acetoxy migration can operate to an adjacent radical center is reflected in the one-step reaction that gives rise to 1,3,4,6-TETRA-O-ACETYL-2-DEOXY-a-D-GLUCOPYRANOSE. 

Asymmetric cyclopropanation.3 The anion of ( + )-l reacts with 2-cyclohexene-1 -ones to form two diastereomeric adducts (2), which are separated by chromatography on silica gel. Cyclopropanation of optically pure 2a or 2b with the Simmons-Smith... 

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