Cyclodextrins nasal preparations

Me, T., Abe, K., Adachi, H. et al. Potential use of 2-hydroxypropyl-(3-cyclodextrin in designing nasal preparations of insulin involving lipophilic absorption enhancer HPE-101. Drug Deliver. Syst. 1992, 7, 91-95. 

In short term studies cyclodextrins caused less histological changes of the nasal epithelium in rats than for instance benzalkonium chloride [24], Other studies in rats showed that dimethyl betacyclodextrin, methylated betacyclodextrin and hydroxypropylbetacyclodextrin are safe and efficient enhancers of nasal absorption [8, 25, 26], These results suggest that cyclodextrins (see also Sect. 18.1.4) can be used in nasal preparations, but more research is still needed. 

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