Cyclodextrins in Molecular Devices

Several physical studies have been carried out on cyclodextrin derivatives. Thus the X-ray structure of per-(6-bromo-6-deoxy-2,3-di-0-methyl)P-cyclodextrin has been examined by single crystal X-ray diffraction analysis. The conformation deviates significantly from C symmetry. Likewise the X-ray structure of heptakis-2,3,6-tri-C>-methyl-P-cyclodextrin shows that one of the seven rings is inverted. Conformational analysis of an extensive set of per-O-substituted p-cyclodextrins reveals that several show conformational isomerism. The relevance of this to the use of cyclodextrins in molecular device design is examined. Related work undertook n.m.r. and molecular modeling studies on a-cyclodextrin in vriiich one of the units is in the 3,6-anhydro from. The work included the examination of two model disaccharide imits. ... 

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