Cyclodextrin further research

Addition of an aqueous solution of PEG to a saturated aqueous solution of a-CD at room temperature did not lead to complex formation unless the average molecular weight of PEG exceeded 200 [46]. Moreover, carbohydrate polymers such as dextran and pullulan failed to precipitate complexes with PEG, and the same was true for amylose, glucose, methyl glucose, maltose, maltotriose, cyclodextrin derivatives, such as glucosyl-a-CD and maltosyl-a-CD, and water-soluble polymers of a-CD crosslinked by epichlorohydrin. These facts suggested to Harada et al. the direction for further research. 

Several artificial receptors such as crown ethers, cyclodextrins, cyclophanes, and calixarenes find applications in molecular recognitions processes. Further, there have been several research publications that focus on computational design and analysis of recognition properties of artificial receptors such as cyclodextrins,15 dendrimers,610 crown ethers,1112 and calixarenes.13 5 Typically computational... 

Despite the recent advances in the development of polymer-based nonviral vectors for siRNA or DNA delivery, the number of formulations that entered clinical trials has been substantially lower than lipid-based nonviral vectors. In this respect, the first-inhuman trial for siRNA delivery was a transferrin-targeted cyclodextrin, CALAA-01 (Fonseca et al., 2014). In 2008, Calando Pharmaceuticals (now part of Arrowhead Research Corporation) started a phase 1 clinical trial with CALAA-01 for the treatment of melanoma (Zuckerman et al., 2014). The rationale relied on the dowmegula-tion of ribonuclease reductase (RRM2) upon transferrin-mediated endocytosis of the siRNA-containing nanoparticle (Zuckerman et al., 2014). However, this nanoparticle was further withdrawn (Fonseca et al., 2014). 

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