Cyclobutane-2,4-dicarboxylic

Calvert AH, Harland SJ, Newell DR, SiddikZH, Jones AC, McElwain TJ, Raju S, WiltshawE, Smith IE, Baker JW, Peckham MJ, Harrap KR. Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II. Cancer Chemotherap Pharmacol 1982 9 140-147. [Pg.59]

The compound given in the problem contains three functionalities that can undergo acid-catalyzed hydrolysis an acetal and two equivalent ester groups. Hydrolysis yields 3-oxo-l,l-cyclobutane-dicarboxylic acid and 2 moles each of methanol and 2-propanol. The hydrolysis product is a malonic... [Pg.599]

A mixture of 0.8 g of [2,2-bis(aminomethyl)-l,3-propanediol-N,N ]dichloroplatinum and 0.78 g of the disilver salt of 1,1-cyclobutane dicarboxylic acid in 50 ml of water was stirred in the dark overnight and then filtered. The filtrate was evaporated to dryness, giving 0.72 g of the desired [2,2-bis(aminomethyl)-l,3-propanediol-N,N ][[l,r-... [Pg.3525]

Alkylation of malonic ester with an equimolar ponion of ethylene bromide or trimethylene bromide produces ring closure to give diethyl esters of 1,1-cyclopropane- and 1,1-cyclobutane-dicarboxylic acids, respectively. Five- and six-membered rings also have been formed in this manner. ... [Pg.250]

Sharma H, Thatcher N, Baer J, Zaki A, Smith A, McAucliffe CA, Crowther D, Owens S, Eox BW. Blood clearance of radioactively labeled cis-diammine 1,1-cyclobutane dicarboxylate platinum [II] [CBDCA] in cancer patients. Cancer Chemother Pharmacol. 1983 11[1] 5-7... [Pg.529]

Harland SJ, Newell DR, SiddikZH, Chadwick R,Calvert AH, Harrap KR. Pharmacokinetics of cis-diammine-1,1-cyclobutane dicarboxylate platinum[ll] in patients with normal and impaired renal function. Cancer Res. 1984 Apr 44[4] 1693-7 Koeller JM,Trump DE,Tutsch KD, Earhart RH, DavisTE,Tormey DC. Phase I clinical trial and pharmacokinetics of carboplatin [NSC 241240] by single monthly 30-minute infusion. Cancer. 1986 Jan 15 57[2] 222-5... [Pg.529]

Scheme 8.23 Carboplatin (Diamine cyclobutane dicarboxylate platinum(II)) cw-diamine-l,l-cy clobutanedicarboxylatoplatinum(II) cii-diamine-(cyclobutane-l,l-dicarboxylato)-platinum(II)...

A series of diamides of cyclobutane-1,1-dicarboxylic acid gre prepared and reported to have depressant properties. The activity of bis 1,1,l-trichloro-2-propyl)-1,2-cyclobutane-dicarboxylate was shown to be due to the in vivo hydrolysis to the known hypnotic 1,1,l-trichloro-2-pro-panol. Preliminary pharmacological results in mice indi-... [Pg.8]

Some organotin carboxylates have structures totally different from those just discussed. For example, Bu2Sn(OOC6H4Br-2)2 is a weakly bridged dimer [497], whereas di-u-butyltin cyclobutane-dicarboxylate, Bu 2Sn(OOC)2C4H6, forms a zigzag polymer [498]. In both compounds tin is six-coordinate octahedral. [Pg.165]

There are two stereoisomeric 1,3-cyclobutane dicarboxylic acids. One can form a cyclic anhydride, the other cannot. [Pg.356]

A better method used irons-cyclobutane dicarboxylate (7.11) and selective hydrolysis of one ester liberated an acid that could be reduced with borane to give 7.12.2 Conversion of that alcohol to a tosylate was followed by reaction with... [Pg.244]

Sodium trans -1,3 - cyclobutanedicarboxylate bis(trans -1,3 - cyclobutane -dicarboxylic acid)... [Pg.173]

Dicycloplatin, a novel supramolecule composed of carboplatin and 1,1-cyclobutane dicarboxylate displayed a favourable safety profile at doses between 50 and SSOmg/m, and first signs of efficacy. Its dose-limited toxicities include thrombocytopenia, anaemia and emesis. The recommended starting dose for a subsequent Phase II study is 450mg/m once every 3 weeks [215 ]. [Pg.314]

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