Cycloartenol ferulate

Phytosterols have been demonstrated as being anti-cancer components in the diet (Awad and Fink 2000). Scientific studies indicate that phytosterols may offer profection against colon, breast and prostate cancers (Vanderhaeghe and Bouic, 2000). The possible mechanisms, as reported by these authors, include the effect of phytosterols on membrane structure and function and on the signal transduction pathways that regulate tumor growth and apoptosis. The rice bran derived phytosterol-cycloartenol-ferulic acid ester on the central nervous system has been studied by Hiraga et al. (1993). 

HIRAGA Y, NAKATA N, JIN H, ITO S, SATO R, YOSHIDA A, MORI T, OZEKI M, IKEDA Y (1993) Effect of the rice bran-derived ph)itosterol cycloartenol ferulic acid ester on the central nervous system. Arzneimittel-Forschung, 43(7) 715-21. 

Cycloartenol ferulic acid ester Bran° ° Cycloeucalenol Sd oiP ° ... 

T. Tamuara, and M. Takido. Inhibitory effect of cycloartenol ferulate, a OS090 component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 1998 ... 

Cycloartenol ferulate 67 Rice bran. y-Oryzanol 0.2 Skin 1 [48]... 

Cycloartenol ferulate (triterpene ferulic ester) Cycloartenol ferulic acid key plant compound precursors HIV-1 RT (2)... 

Yasukawa, K. Akihisa, T. Kimura, Y. Tamaura, T. Takido, M. 1998. Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin. Biol. Pharmaceut. Bull. 21 1072-1076. Zhou, M. Robards, K. Gleimie-Holmes, M. Helliwell, S. 1999. Oat lipids. J. Am. Oil Chem. Soc. 76 159-169. 

Dimethyl sterols are also intermediates in plant sterol biosynthesis and can be found in only trace amounts in most plants. Some plant materials such as rice bran oil (see Chapter 4) have elevated levels of 4,4-dimethyl sterols such as cycloartenol and 24-methyl cycloartenol. The content of 4,4-dimethyl sterols in rice bran oil sterols varies, probably with the rice variety and processing conditions. According to de Deckere and Korver (1996), crude rice bran oil contains 1.8,0.4 and 1.2 g/100 g oil of 4-desmethyl, 4-methyl and 4,4-dimethyl sterols, respectively, mainly as esters of ferulic andp-coumaric acids. 

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