Cyclic nucleotides guanylyl cyclase

Synthesized by soluble guanylyl cyclase and particulate guanylyl cyclase from guanosine triphosphate (GTP). Nitric oxide activates soluble guanylyl cyclase to enhance cyclic GMP production that contributes to various NO actions. Cyclic GMP is hydrolyzed by phosphodiesterases. Cyclic GMP binds to and activates cGMP-dependent protein kinase, phosphodiesterases, and Cyclic Nucleotide-regulated Cation Channels. [Pg.399]

Adenylyl Cyclases Guanylyl Cyclases Transmembrane Signalling Cyclic Adenosine Monophosphate Cyclic Guanosine Monophosphate Cyclic Nucleotide-gated Channels Phosphodiesterases... [Pg.403]

As shown in Figure I, the cyclic nucleotides cAMP and 3, 5 guanosine cyclic monophosphate (cGMP) are formed by the action of adenyl cyclase (AC) or guanylyl cyclase (GC) on their... [Pg.69]

The cyclic nucleotides adenosine 3, 5 -cyclic monophosphate (cyclic AMP (cAMP)) and guanosine 3, 5 -cyc.lic monophosphate (cyclic GMP (c.GMP)) are second messengers generated by adenylyl (adenylate) cyclase (AC) and guanylyl (guanylate) cyclase (GC), respectively, in response to receptor occupation by particular primary messengers , that is,... [Pg.253]

For the receptors that bind atrial natriuretic peptides and the peptides guanylin and uroguanylin, the intracellular domain is not a protein kinase but rather a guanylyl cyclase that synthesizes the second messenger cyclic guanosine monophosphate (cyclic GMP), which activates a cyclic GMP-dependent protein kinase (PKG) and can modulate the activities of several cyclic nucleotide phosphodiesterases, among other effectors. [Pg.16]