Cyanobacterial origin

As illustrated by the cases of an antilarval defense in U. reticulata produced by a Vibrio sp. bacterium and by the likely cyanobacterial origin of lobophorolide,... 

Luesch, H., Yoshida, W. Y., Moore, R. E., and Paul, V. J. (2002). New apratoxins of marine cyanobacterial origin from guam and palau. Bioorg. Med. Chem. 10,1973-1978. 

New thiazole-containing cyclicpeptides were reported very recently. Homodolastatin 3 (479) and kororamide (480) were isolated from a Palau collection of the macroscopic cyanophyte Lingbya majuscula. The structures of 479 and 480 were determined by interpretation of their spectroscopic data and chemical degradation. This work constitutes an additional support of the cyanobacterial origin of the dolastatin peptides [364]. 

Luesch H, Harrigan GG, Goetz G, Horgen FD (2002) The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares. Curr Med Chem 9 1791... 

Dolastatins 11, 12 79, 81, first isolated from the sea hare Dolahdla auricularia and now clearly considered to be of dietary cyanobacterial origin, can be mentioned as examples [133]. The structurally closely related cyclodepsipeptide majuscula-mide C 80 has been isolated from defined cyanobacterial sources [119]. This was one and a half decades before dolastatin 12 81 was furthermore detected in extracts from a marine cyanobacteria assemblage (Lyngbya majuscula/ Schizothrix calcicola)... 

Further aliphatic a-methyl-/ -amino acids, for example Amha 69, Admpa 70, and Amoa 73, have been found in peptidic natural products from marine animals and from cyanobacteria. Although dolastatin D 82 and dolastatin 17 83 have so far been obtained from sea hare isolates only, these peptides should now be considered to be of cyanobacterial origin, as indicated by their p-amino acid substructures, i.e. Amba 67 and Aoya 72. 

Dolastatin 18 (32) (Figure 7) also contains significant biosynthetic signatures that imply that it is of cyanobacterial origin. These include a 2,2-dimethyl-1,3-dicarbonyl moiety found in lyngbyastatin 1 (4a) and majusculamide C (6) and a dolaphenine residue found in symplostatin 1 (10) and barbamide (11). 

Moroder, L. and Rudolph-Bohner, S. (1998) Microcystins and nodularins, hepatotoxic cyclic peptides of cyanobacterial origin, in Studies in Natural Product Chemistry (ed. Atta-Ur-Rahman), vol. 20, pp. 887-920. 

Luesch, H., Harrigan, G.G., Goetz, G., and Horgen, F.D. (2002) The cyanobacterial origin of potent anticancer agents originally isolated from sea hares. Curr. Med. Chem., 9,1791-1806. 

The cyanobacterial origin of aurilide seems to be confirmed by the identification of auribdes B and C in Lyn ya majuscula from Papua New Guinea (Han et al, 2006). 

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