Lingbya majuscula

Curacins (345-348) are a small family of bioactive compounds with a unique thiazoline-containing lipid bearing a cyclopropane unit. From the cyanobacterium Lingbya majuscula, Gerwick reported the isolation of curacin A (345) in 1994 [265], curacins B (346) and C (347) one year later [266] and, finally, curacin D (348) in 1998 [267]. The structures of these compounds were determined by detailed spectroscopic analysis. The previous absolute configuration proposed for 345 by chemical degradation [268] was confirmed by several total syntheses [269, 270]. The absolute configuration of 346 was deduced by its thermally induced interconversion with 345 [266]. 

New thiazole-containing cyclicpeptides were reported very recently. Homodolastatin 3 (479) and kororamide (480) were isolated from a Palau collection of the macroscopic cyanophyte Lingbya majuscula. The structures of 479 and 480 were determined by interpretation of their spectroscopic data and chemical degradation. This work constitutes an additional support of the cyanobacterial origin of the dolastatin peptides [364]. 

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