Cyclodepsipeptides, cyanobacterial

Scheme 1.5.12. Cyanobacterial cyclodepsipeptides with aliphatic / -amino acid substructures.

A similar approach has been reported for the total synthesis of the marine cyanobacte-rial apratoxin A (111). Apratoxin A, isolated from Lyngbya spp. cyanobacteria, is representative of a growing class of marine cyanobacterial cyclodepsipeptides wherein discrete polypeptide and polyketide domains are merged by ester and amide or amide-derived linkages. For the preparation of apratoxin A, the reaction of the azide 109 with... 

Dolastatins 11, 12 79, 81, first isolated from the sea hare Dolahdla auricularia and now clearly considered to be of dietary cyanobacterial origin, can be mentioned as examples [133]. The structurally closely related cyclodepsipeptide majuscula-mide C 80 has been isolated from defined cyanobacterial sources [119]. This was one and a half decades before dolastatin 12 81 was furthermore detected in extracts from a marine cyanobacteria assemblage (Lyngbya majuscula/ Schizothrix calcicola)... 

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