Cyano- -methyl ester

Acetic acid, (4-chloro-2-oxobenzothiazolin-3-yl)- — see Benazolin Acetic acid, cyano-methyl ester... 

Abietylamine, dehydro-, A tnfluoro- [Acetamide, 2,2,2-trifluoro-/V-[ [1,2,3,4,4a, 9,10,1 Oa-octahydro-l, 4a-dtmethyl-7-(l-methylethyl)-l -phenanthrenyl ] -methyl]-, [17 (la,4ad,10aa))-, 125 Acetamides, A-arylalkyl-, 7 Acetanilide, 2,2,2-tnfluoro- [Acetamide, 2,2,2-tnfluoroTV-phenyl-], 122 Acetic acid, cyano-, methyl ester, 63 Acetic acid, methoxy-, 70 Acetic acid, phenoxy-, 68 Acetic acid, phenyl- [Benzeneacetic acid],... 

Acetic acid, chloro, tert butyl ester, 55, 94 Acetic acid, cyano-, ethyl ester, 55, 58, 60 Acetic acid, cyano-, methyl ester, 56, 63 Acetic acid, 3,4-dimethoxy-phenyl-, 55,45, 46... 

METHYL oi-CYANOPELARGONATE (Pelargonic acid, 0-cyano-, methyl ester)... 

Pelargonic acid, 8-cyano-, methyl ESTER, 25, 69 o-Pelargonylphenol, 20, 58 -Pelargonylphenol, 20, 58 PENTAACETYL-d-GLUCONONITRJXE, 20, 14, 74... 

Bifunctional catalysis. Some time ago Swain and Brown1 observed that 2-hydroxypyridine catalyzed the mutarotation of tetramethylglucose by a concerted base-acid catalysis and that it is more effective than pyridine plus phenol. A few years later Beyerman and van den Brink2 showed that 2-hydroxypyridine and other bifunctional compounds catalyze the reaction of amines with cyano-methyl esters (reactive esters) as well as low-energy esters in peptide synthesis. Pyrazole and 1,2,4-triazole (1,1188), were equally effective. 

Beilstein Handbook Reference) Acetic acid, cyano-, methyl ester AI3-05599 BRN 0773945 Cyanoacetic acid methyl ester EINECS 203-288-8 Methyl cyanoacetate Methyl cyanoethanoate Methylester kyseliny kyanoctove NSC 3113 USAF KF-22. Used in organic synthesis and manufacture of pharmaceuticals and dyes. Liquid mp = -22.5° bp = 200.5° d = 1.1225 insoluble in H2O, very soluble in EtOH, Et20. Degussa-Huls Carp. GreeffR.W. Co. Lonzagroup. 

Carbamic acid, cyano-, methyl ester EINECS 244-548-0 Methyl cyanocarbamate. 

The rate of reaction of carboxylic esters with amines can often be increased by using as acylating agents esters that exchange their alcohol residues with particular ease. With this in mind Schwyzer781 recommends the use of cyano-methyl esters, RCOOCH2CN. The cyanomethyl esters of N-protected amino acids react readily even at room temperature with amino esters and are thus particularly suitable for peptide synthesis. Also, phenyl trifluoroacetate has been recommended for trifluoroacetylation of amino acids and peptides.782 The possibilities offered by such activated esters for peptide synthesis are reviewed in the monograph by Schroder and Liibke.783... 

Synonyms ACC Acrylic acid, 2-cyano-, methyl ester 2-Cyanoacrylic acid, methyl ester a-Cyanoacrylic acid, methyl ester 2-Cyano-2-propenoic acid, methyl ester Mecrylate Methyl cyanoacrylate Methyl-a-cyanoacrylate Methyl 2-cyano-2-propenoate 2-Propenoic acid, 2-cyano-, methyl ester Empirical C5H5NO2 Formula CH2 C(CN)COOCH3 Properties Colorless to si. yel. clear liq. acrid odor sol. 1-10 mg/ml in DMSO sol. < 1 mg/ml in water, 95% ethanol, acetone m.w. 111.10 sp.gr. 1.1044 (27/4 C) b.p. 47-49 C (1.8 mm) flash pt. 78.9 C... 

Poly(2-propenoic acid, 2-cyano-, methyl ester-co-ethenyl benzene) See image). 

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