CXCR4 as a Therapeutic Target

Patho-Physiological Role of CXCR4 Potential as a Therapeutic Target 249... 

Oh et al, 2001), suggests that CXCR4 may be not only an important contributor to CNS tumor biology but one with broad potential as a therapeutic target. 

The pathological role of CXCR4 in many diseases has boosted the search of therapeutic molecules targeting the receptor. Notably, the discovery of CXCR4 as a co-receptor for HIV has initiated this research area over the past two decades and lead to identification of various molecules that alter CXCR4 functions. Such large... 

As noted above, CXCR4 expression is regulated by hypoxia in many human tumors, and thus would serve as a potential therapeutic target for inhibiting tumor growth. 

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