Cw-Diamminedichloroplatinum

Wakatsuki, K., et al. 2005. Effects of irradiation combined with cw-diamminedichloroplatinum (CDDP) suppository in rabbit VX2 rectal tumors. World J Surg 29 388. 

P.J. Parsons and A.F. LeRoy, Determination of cw-diamminedichloroplatinum(II) in human plasma using ion-pair chromatography with electrochemical detection, J. Chromatogr., 1986, 378, 395-408. 

Cisplatin, cw-diamminedichloroplatinum(II), is an extremely potent antitumor agent. Show how it can be prepared in high purity to the exclusion of the trans geometric isomer by employing the kinetic trans effect. 

Cisplatin is the commercial name of ds-diamminedichloroplatinum(II), which is widely used as an approved drug since 1978 for treating a variety of tumors. In the crystal structure, Z = 2, and the cw-PtCl2(NH3)2 molecule was found to occupy a general position. The measured dimensions and crystal packing are shown in Fig. 9.6.2. 

Due to the anticancer activity of some amine-coordinated Pt compounds, there has been extensive interest in the complexes of Pt with oligonucleotides and nucleotides. These Pt complexes normally have square planar geometry and, in the case of bases and dinucleotides, can template more extensive supramolecular structures. Certain cw-Pt complexes are highly effective anticancer agents, the most famous being cisplatin or d5-diamminedichloroplatinum(II) and a related compound, carboplatin, cM-diammine(cyclobutane-l,l-dicarboxylato)platinum(II). There have been extensive studies of the coordination properties of Pt compounds with nucleic acid bases to further understand the effect of these drugs on DNA structure and function. ... 

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