Cushman

M. Schoen, D. J. Diestler, J. H. Cushman. Fluids in micropores. I. Structure of a simple classical fluid in a slit-pore. J Chem Phys 27 5464-5476, 1987. 

Cushman, W. H., Rosenberg, D. J. (1991). Advances in Human Factors/Ergonomics, Human Factors in Product Design. New York Elsevier. 

An important extension of the Knorr pyrrole synthesis developed by Cushman utilizes ketone enolates and BOC-protected a-amino aldehydes and ketones. Two examples (37, 38) are shown. 

Cushman P, Dole VP Detoxification of rehabilitated methadone-maintained patients. JAMA 226 747-752, 1973... 

Alternatively, Cushman has devised a facile route to pyrroles by the reaction of Boc-a-amino aldehydes or ketones 14 with the lithium enolates of ketones 15 to afford aldol intermediates 16 which cyclize to pyrroles 17 under mild acidic conditions <96JOC4999>. This method offers several advantages over the Knorr since it employs readily available Boc-a-amino aldehydes or ketones and utilizes simple ketones instead of the p-diketo compounds or p-keto esters normally used in the Knorr. 

Cushman DW, Cheung HS, Sabo EF, Ondetti M A. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoal-kanoyl amino acids. Biochemistry 1977 16 5484-91. 

It is a pleasure to acknowledge stimulating discussions with Richard Cushman and Boris Zhilinskii, who introduced the author to this interesting field. He is particularly grateful to ZhiUnskii for constructive comments on an initial draft, which led to substantial improvements to the chapter. 

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