Cushingoid syndrome

Iatrogenic Cushingoid syndrome — fat deposition, muscle weakness/atrophy, bruising,... 

Adverse reactions Primarily a catabolic effect on muscle, bone, ligament, tendon suppression of hypothalamic-pituitary-adrenal pathway Cushingoid syndrome with long-term use other effects include euphoria, insomnia, psychotic behavior, pseudotumor, mental changes, nervousness, restlessness, heart failure, hypertension, edema, acute tendon ruptures, delayed wound healing... 

The manufacturer notes that the use of ketoconazole with ciclesonide increase the serum levels of the active metabolite of ciclesonide 3.5-fold and that an increased risk of adverse effects such as Cushingoid syndrome carmot be excluded. ... 

Cushingoid features Truncal obesity Withdrawal syndrome... 

Figure 1 Photographs of a 17-year-old male patient who had Bechet s syndrome for three years which required treatment with long-term systemic corticosteroids as well as immunosuppressive drugs. Note the pronounced corticosteroid-induced side effects including skin striations and Cushingoid appearance.

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