Curcumin natural analogs

Turmeric has been used for the treatment of inflammation for thousands of years in Asian countries. The active constituents were found to be curcuminoids, including curcumin as well as its two natural analogs, demethoxycurcumin and bisdemethoxycurcumin [7], Demethoxycurcumin showed the most potent anti-inflammatory activity among these three natural curcuminoids [8]. According to present studies, curcumin acts by diverse anti-inflammatory mechanisms and at several sites along the inflammation pathway, which are summarized in Fig. (3) [9]. 

Lin L, Lee KH. Structure-activity relationships of curcumin and its analogs with different biological activities. In Studies in Natural Products Chemistry, Volume 33. Ur-Rahman A, ed. Elsevier, New York, pp. 785-812. 

In order to search for new chemopreventive enzyme inducers and to elucidate the structural features responsible for the ability of curcumin to induce Phase 2 detoxification enzymes, Dinkova-Kostova et al.[48, 49] examined some natural as well as synthetic curcumin analogs for ability to induce NAD(P)H quinone reductase (a prototype for phase 2 detoxification enzymes) in murine hepatoma cells. Compounds... 

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