Cumulative Subject complexes

Aeeurate measurement of harmonic quantities and their cumulative effect is a complex subject, and is not possible to determine theoretically with the help of algebraic equations. But it can be easily measured with the help of a harmonic analyser. Cigre (1989) has made a comprehensive study of the likely harmonics and their amplitudes that may be present in a power system. These are briefly described in Table 23.1. 

The Formula Index, as well as the Subject Index, is a cumulative index for Volumes XVI, XVII, XVIII, and XIX. The chief aim of this index, like that of other formula indexes, is to help in locating specific compounds or ions, or even groups of compounds, that might not be easily found in the Subject Index, or in the case of many coordination complexes are to be found only as general entries in the Subject Index. All specific compounds, or in some cases ions, with definite formulas (or even a few less definite) are entered in this index or noted under a related compound, whether entered specifically in the Subject Index or not. 

These studies demonstrated that DNA-binding can be a reliable probe of metabolic activation. In contrast to studies of metabolites per se, which usually involve large numbers of metabolite intermediates, DNA-binding monitors only chemically reactive metabolites. Also, if there is no selective repair of specific adducts, DNA-binding monitors the cumulative production of metabolites over time, while direct measurement of metabolites can show the metabolite spectrum only at the time observed. This can be particularly critical for studies of activation of complex chemicals such as polycyclic aromatic hydrocarbons whose primary metabolites are subject to secondary and tertiary metabolism (8). 

We now come to the subject of simplified reaction-center complexes, which have been found to be particularly valuable for the study of various components along the electron-transport chain in photosystem I. The basic strategy used for obtaining simplified PS-I reaction-center complexes was to selectively remove the components one-by-one cumulatively along the electron-carrier sequence, starting from the terminal end of the chain. 

Regulation of HMG-CoA reductase protein levels is mechanistically complex and subject to multivalent feedback control [141]. The following lines of evidence indicate that HMG-CoA reductase responds to multiple regulatory signals which exert independent, cumulative effects ... 

The Subject Index is a two-yearly cumulation covering both Volume 43 and 44, and is supported by an updated Formula Index of Complex Functional Groups (p. 493) for rapid access to functional group nomenclature (the formula OSiCj, for example, indicating that the function RjSiO —C = C is indexed as Enoxysilanes in the Subject Index). 

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