Cumulative insulin release from

Figure 9. Release kinetics of bovine insulin released from an ATRIGEL formulation (60% PLG, inherent viscosity 0.13). Formulation solvent was NMP, and the peptide load was 1%. Cumulative release profiles were generated in PBS, pH 7.4.

Figure 10. FPLC chromatograms of bovine insulin eluted from a Cjg column (A) 80-/

When disks containing insulin dispersed in the polymer were subjected to well controlled low pH pulses and the cumulative amount of insulin released during each pulse determined by radioimmunoassay, the results shown in Fig. 20 were obtained. The progressive decrease with repeated stimulation represents a gradual depletion of insulin from the device. 

FIGURE 4.8 (A) Cumulative release of triptorelin and leuprolide from lipospheres. Lipospheres were prepared from L-PLA and HSPC, as described in Figure 4.6. The release experiment was performed in pH 7.4, phosphate buffer, at 37°C, and analyzed by HPLC for both formulations. (Adapted from [35] with permission from Elsevier.). (B) Comparison of release profiles of thymocartin (loading 9.0%), somatostatin (loading 9.3%), and insulin (loading 6.83%) from glyceryl tripalmitate microparticles. (Adapted from [37] with permission from author.)... 

Figure 8. Cumulative amount of released insulin from ReGef formulation in vitro test. ...

Figure 6. Cumulative release (Mt/Mo) of Insulin ( ) and p iactoglobulln (O) from FAXMB gels (a) as a function of time and (b) as a function of root time. Protein release was followed at 25°C and 90 rpm during 15 h. Gels at 3.5% (w/v) In FAXMB and 0.1% (w/v) protein.

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