Cultural significance, consolidation

Serious physical and ethical problems inherent to the consolidation process are apparent. A relationship exists between those problems and the extent of consolidation As more consolidant is introduced into the artifact, adulteration of cultural significance also increases. Therefore, only the minimum effective consolidation (MEC) should be applied. A thorough evaluation of the object and its anticipated environment is essential to determine what is effective. 

Predictable transition-phase properties are critical, particularly in simple consolidation and during the initial stages of complex consolidation. Exothermal reactions, swelling, and shrinking are common physical occurrences during the polymerization process. Permanent hidden and overt alterations that can occur during the set time may further diminish the cultural significance of an artifact. 

Bestatin (ubenimex) is a potent inhibitor of aminopeptidase N and aminopeptidase B,89 which was isolated from a culture filtrate of Streptomyces olivoreticuli during the search for specific inhibitors of enzymes present on the membrane of eukaryotic cells.90 Inhibitors of aminopeptidase activity are associated with macrophage activation and differentiation, Bestatin has shown significant therapeutic effects in several clinical trials.91 In a multi-institutional study,92 patients with acute non-lymphocytic leukemia (ANLL) were randomized to receive either Bestatin or placebo orally after completion of induction and consolidation therapy, and concomitant with maintenance chemotherapy. Remission duration was prolonged in the Bestatin group, although this difference did... 

Moreover, the quaUty of materials and intervention works is of primary importance for the longevity and economy of interventions. However, the system of regulations, recommendations, proper test methods, and specific standards has not been fuUy developed, in spite of continuous efforts of the last decade on national and European level. There is still a gap between knowledge and practice, but undoubtedly the continuous education and joint research efforts, as well as the awareness of the society about safeguarding cultural patrimony, have resulted in significant improvement of consolidation and strengthening works. 

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