CSRS

Clip acts in phase (the same Fourier component) with the first action of cii to produce a polarization that is anti-Stokes shifted from oi (see fV (E) and IFj (F) of figure B 1.3.2(b)). For the case of CSRS the third field action has frequency CO2 and acts in phase with the earlier action of CO2 (W (C) and IFj (D) of figure Bl.3.2 (b). Unlike the Class I spectroscopies, no fields in CARS or CSRS (or any homodyne detected Class II spectroscopies) are in quadrature at the polarization level. Since homodyne detected CRS is governed by the modulus square of hs lineshape is not a synmretric lineshape like those in the Class I... 

Plenary 7(5. N I Koroteev et al, e-mail address Koroteev nik.phys.iusu.su (CARS/CSRS, CAHRS, BioCARS). A survey of the many applications of what we call the Class II spectroscopies from third order and beyond. 2D and 3D Raman imaging. Coherence as stored infonuation, quantum infonuation (the qubit ). Uses tenus CARS/CSRS regardless of order. BioCARS is fourtli order in optically active solutions. 

Dugan M A, Melinger J S and Albrecht A C 1988 Terahertz oscillations from molecular liquids in CSRS/CARS spectroscopy with incoherent light Chem. Rhys. Lett. 147 411-19... 

Joe T, Dugan M A and Albrecht A C 1991 Time resolved coherent Stokes Raman spectroscopy (CSRS) of benzene Chem. Phys. Lett. 177 4-10... 

The terms (CSR) and (Atfe + AboV s have a similar order of magnitude in chemical processing. For example, (CSR) values of 0.1 to 0.4 are typical, and these are qmte close to a value of 0.2 that is common in general chemical processing for (Atfe + AboV s- Thus, the profit margin is very sensitive to the value Cinv per unit of inventory. 

Two well-known ratios used by financial analysts are the profit-to-sales ratio (PSR) and the contribution-to-sales ratio (CSR). The profit-to-sales ratio is simply Eq. (9-127) for profit margin (PM) rewritten as the ratio... 

Table 2-6. The effeets of organie modifier on the separation of amino aeids on teieoplanin CSR a...

Fig. 2-15. Reversed-phase retention of the first eluted and the seeond eluted enantiomers of 5-methyl-5-phenylhydantoin as a funetion of mobile phase eomposition. The eolumn was a 250 x 4.6 mm vaneomyein CSR The buffer was triethylammonium aeetate at pH 7.0. The flow rate was 1.0 mL min at ambient temperature (23 °C).

This method represents the most common and traditional application of computational tools to rational drug design. From a list of molecules of known activity, one can establish a 3D-pharmacophore hypothesis that is then transformed into a 3D-search query. This query is then used to search a 3D database for structures that fit the hypothesis within a certain tolerance. If the yield of active molecules is significant, then the query can be used to predict activities on novel compounds. In our situation, the enantiophore is built from the superposition of a list of sample molecules, which are all well separated on a given CSR Hence, the common features of this series of molecules can become a good enantiophore hypothesis for the enantiores-olution on this CSR... 

Starting from a collection of samples remarkably well resolved (alpha > 6) on Chiralcel OD (Cellulose tris(3,5-dimethylphenylcarbamate) coated on aminopropyl silica), a putative three-point enantiophore for binding to CSR was derived (Fig. 4-10). This enantiophore query was used to search (CFS 3D search) within a list comprising 4203 compounds tested on Chiralcel OD. From this search domain of CHIRBASE 3D, 191 structures were found to match the enantiophore. 

The best resolution of Q-branch rotational structure in a N2-Ar mixture was achieved by means of coherent anti-Stokes/Stokes Raman spectroscopy (CARS/CSRS) at very low pressures and temperatures (Fig. 0.4). A few components of such spectra obtained in [227] are shown in Fig. 5.9. A composition of well-resolved Lorentzian lines was compared in [227] with theoretical description of the spectrum based on the secular simplification. The line widths (5.55) are presented as... 

Fig. 5.9. Examples of experimental and fitted CSRS spectra of nitrogen in argon from [227] at 140 K under total pressure 200 Torr (a) and 600 Torr (b), N2 Ar=l 10 ( ) observed (----) calculated.

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