Crystal Engineering of Solid State Photochemical Reactions

1 Crystal Engineering of Solid State Photochemical Reactions 

Reactants functionalized with self-complementary hydrogen bonding groups have been used to steer molecules into necessary arrangements for reaction. Feldman and Campbell [95] demonstrated that a J -shaped naphthoic acid-derived cinnamic acid 59 could assemble to a dimer in the solid state through carboxylic acid synthons, where the HT alignments of two olefins conform to the topochemical criteria 

In nature, enzymes provide well-tailored microenvironments for highly substrate-specific and stereoselective reactions at ambient conditions. Nature is always the most important source of inspiration for chemists. There has long been great interest in designing artificial cavities that possess comparable efficiency and selectivity as enzymes. Often, reactions of prearranged molecules in confined environment of designed cavities can proceed at enhanced rate and with unusual regio- or stereoselectivity. 

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