Cross phenylpyrroles

In Botrytis, dicarboximide and phenylpyrrole resistant laboratory strains [12,18] and less sensitive field isolates [13, 19] are usually found to be mutated in Dafl, the histidine kinase homologous to Os-1. However, field isolates less sensitive to dicarboximide fungicides were reported to retain wild-type levels of sensitivity to phenylpyrroles [18-20]. Vignutelli et al. [21] crossed a field resistant strain of Botrytis with a sensitive one and found that dicarboximide resistance segregated separately from phenylpyrrole resistance, suggesting different genes regulate... 

The inherent risk for development of resistance towards phenylpyrroles is considered as medium [39]. No cross-resistance has been reported between phenylpyrroles and products of other chemical classes, including benzimidazoles, dicarboximides, N-phenylcarbamates and anilinopyrimidines for B. cinerea [40]. 

Synthesis by Direct Cross-Coupling Reaction Trauner and co-workers and Bowie and Trauner reported on a concise total synthesis of racemic rhazinilam 122 and rhazinal 123, axially chiral phenylpyrroles having potent antimitotic properties, through an aromatic C—H activation (Scheme 23.24). " To construct the lactam ring of the title compounds, the authors proposed the use of a palladium-catalyzed direct intramolecular cross-coupling reaction. 

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