Cross-linking monomers dimethacrylate Trimethylolpropane

The template, the functional monomers and the cross-linking monomers are dissolved in a non-polar solvent. The functional monomers and the template form complexes and the strength of these are reflected in the selectivity of the imprinted polymer. The choice of functional monomer is based on the template structure. Functional monomers are chosen for their ability to interact non-covalently with the template molecule. The most frequently used functional monomer so far is methacrylic acid (MAA). Also vinylpyridines have been frequently used. As cross-linking monomers, ethyleneglycol dimethacrylate (EDMA) or trimethylolpropane trimethacrylate (TRIM) are widely used. Several other types of functional and cross-linking monomers have been used in molecular imprinting experiments using the non-covalent approach. The choice of monomers is of course important to the... 

Figure 5 Selection of common cross-linkers used in molecular imprinting protocols. Both ethyleneglycol dimethacrylate (EDMA) and divinylbenzene (DVB) are very common crosslinkers in molecular imprinting. Other acrylate-based cross-linking monomers conunonly used include the branched cross-linker trimethylolpropane trimethacrylate (TRIM)-[24]. Among the water-soluble cross-linkers, there are phenylene-diacrylamide, V,V-methylene diacrylamide [22], and Z w-acryloylpiperazine [92], which have been used in aqueous systems for the imprinting of, e.g., enzymes.

Traditional noncovalent MIPs employ functional monomers such as methacrylic acid (MAA) or 4-vinylpyridine (4-Vpy) and cross-linking monomers such as divinyl benzene (DVB), ethylene glycol dimethacrylate (EDMA), or trimethylolpropane... 

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