Cross-coupling Reactions of Alkyl Electrophiles

Table 4 Negishi cross-coupling reactions of alkyl electrophiles and organozinc halides...

Negishi E, Tan Z (2005) Diastereoselective, Enantioselective, and Regioselective Carbo-alumination Reactions Catalyzed by Zirconocene Derivatives. 8 139-176 Netherton M, Fu GC (2005)Pa]ladium-catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds. 14 85-108 Nicolaou KC, King NP, He Y (1998) Ring-Closing Metathesis in the Synthesis of EpothUones and Polyether Natmal Products. 1 73-104 Nishiyama H (2004) Cyclopropanation with Ruthenium Catalysts. 11 81-92 Noels A, Demonceau A, Delaude L (2004) Ruthenium Promoted Catalysed Radical Processes toward Fine Chemistry. 11 155-171... 

Netherton M, Fu GC (2005) Palladium-catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds. 14 85-108 Neumann H, see Jacobi von Wangelin A (2006) 18 207-221... 

Fig.l Cross-coupling reaction of unactivated alkyl electrophiles showing intramolecular p-hydride elimination (undesired) and intermolecular transmetalation (desired). 

Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles 87... 

The Suzuki cross-coupling methods described in Sect. 2.1 establish that palladium complexes that bear electron-rich trialkylphosphines of the appropriate size can serve as effective catalysts for reactions of alkyl electrophiles. Naturally, it was of interest to determine if non-phosphine ligands that are bulky and electron-rich can also furnish active catalysts. 

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