Cross-Coupling of Alkynl Halides with Amides or Carbamates

3 Cross-Coupling of Alkynl Halides with Amides or Carbamates 

Under the catalysis of CuCN/DMEDA (Lll), ynamides could be conveniently synthesized via N-alkynylation of amides, including oxazolidinones, lactams and 

Br Lll arylamide, alkylamides lactam, oxazolidinones Cul, CsjCOj (or K2CO3), THF (or toluene), RT-110°C [38] 

4 I LI 5 arylamide, alkylamides lactam, oxazolidinones Cu(CH3CN)4Pp6 Rb2COj, DMA, 45-60°C [40] 

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