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Craniofacial malformations

Mice homozygous for an ETA receptor gene disruption show craniofacial malformations, such as cleft palate, micrognathia, microtia and microglossia. ETA (—/—) mice die shortly after birth due to respiratory failure. Mice with an ET-l-null mutation show the same cranciofacial malformations and, in addition, cardiovascular disorders (e.g. septal defects, abnormal cardial outflow tract, aortic arch and subclavian arteries). [Pg.475]

Gaffield, W. and Keeler, R.F. (1996). Steroidal alkaloid teratogens molecular probes for investigation of craniofacial malformations, J. Toxicol. Toxin Rev., 15, 303-326. [Pg.67]

Fish-specific TEFs of halogenated diphenyl ethers have been low also in a rainbow trout early life stage mortality bioassay [85]. Halogenated diphenyl ethers were inactive in this bioassay, whereas polyhalogenated dibenzo-p-dio-xins, dibenzofurans, and biphenyls reduced growth and produced yolk sac edema and craniofacial malformations. PCDEs 71, 77, 102, 118, and 126 and PBDEs 47,85, and 99 were analyzed in this bio assay. [Pg.174]

That said, chemicals that have demonstrated or are considered likely to cause specific craniofacial malformations are tested preferentially in whole embryo culture because of its ability to faithfully recapitulate craniofacial development. [Pg.173]

Three major types of craniofacial malformations were induced in hamsters upon oral adminstration of Veratrum alkaloids during the primitive streak/neural plate development phase which is on the eighth day of the hamsters 16 day gestation period [42]. These primary malformations include exencephaly. Fig. (5), which is a fully-exposed... [Pg.570]

Kleinheinz J, Stamm T, Meier N, Wiesmann HP, Ehmer U, Joos U (2000) Three-dimensional magnetic resonance imaging of the orbit in craniofacial malformations and trauma. Int J Adult Orthodon Orthognath Surg 15 64-68... [Pg.181]

Pelo S, Tassiello S, Boniello R, Gasparini G, Longobardi G (2006) A new method for assessment of craniofacial malformations. J Craniofac Surg 17 1035-1039... [Pg.182]

Craniofacial malformation are common features of FAS, which impairs the normal development of the skull, jaws, teeth, nose, eyes, and facial skin. Sometimes variable anomalies of limbs and joints are present, including congenital hip dislocations, abnormalities of the toes, and inability to extend completely the elbows or metacarpal phalangeal joints. Cardiac malformations syndrome encompasses an atrial septal defect, a patent ductus arteriosis, and cardiac murmurs representing ventricular septal defects. Anomalies of external genitalia have also been noted. [Pg.22]


See other pages where Craniofacial malformations is mentioned: [Pg.120]    [Pg.181]    [Pg.275]    [Pg.132]    [Pg.136]    [Pg.175]    [Pg.764]    [Pg.14]    [Pg.15]    [Pg.318]    [Pg.68]    [Pg.566]    [Pg.572]    [Pg.577]    [Pg.584]    [Pg.28]    [Pg.454]    [Pg.128]   
See also in sourсe #XX -- [ Pg.154 ]




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Craniofacial

Malformations

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