Cranial radiation therapy

Shaw, E., Scott, C., Suh, J., Radish, S., Stea, B., Hackman, J., Pearlman, A., Murray, K., Caspar, L., Mehta, M., Curran, W., and Gerber, M. RSR13 plus cranial radiation therapy in patients with brain metastases comparison with the Radiation Therapy Oncology Group Recursive Partioning Analysis Brain Metastases Database./. Clin. Oncol. 2003, 21, 2364-2371. 

Mamon HJ, Wen PY, Bnrns AC, Loeffler JS. Allergic skin reactions to anticonvnlsant medications in patients receiving cranial radiation therapy. Epilepsia 1999 40(3) 341. ... 

Mulhern RK, Ochs J, Kun LE Changes in intellect associated with cranial radiation therapy, in Radiation Injury to the Nervous System. Edited by Gutin PH, Leibel SA, Sheline GE. New York, Raven, 1991, pp 325-340... 

Verzosa MS, Aur RJA, Simone JV, et al Five years after central nervous system irradiation of children with leukemia. Int J Radiat Oncol Biol Phys 1 209-215, 1976 Waber DP, Shapiro BL, Carpentieri SC, et al Excellent therapeutic efficacy and minimal late neurotoxicity in children treated with 18 grays of cranial radiation therapy for high-risk acute lymphoblastic leukemia a 7-year follow-up study of the Dana-Farber Cancer Institute Consortium Protocol 87-01. Cancer 92 15-22, 2001 Wachowski TJ, Chenault H Degenerative effects of large doses of roentgen rays on the human brain. Radiology 45 227-246, 1945... 

Concurrent therapy for the treatment of more than three brain metastases using paclitaxel and radiation has been explored in a phase III trial (144). The hypothesis here being that high-dose paclitaxel in combination with cranial radiation should improve local control while providing systemically active amounts of chemotherapy. Unfortunately, there was no statically significant improvement in survival seen. There is certainly a place to further explore the benefits and toxicides experienced with concurrent taxane-based therapy with radiation in metastatic disease. The role of the taxanes in concurrent chemoradiotherapy with sarcomas and pediatric tumors has not been explored at this time. 

MacDonald D. A Phase I study of Topotecan plus cranial radiation for glioblastoma multiforme a report of Radiation Therapy Oncology Group (RTOG) study 95-07. Proc Am Soc Thera Rad Oncol. Int J Radiat Oncol Biol Phys 1997 39 271. 

---