Covalent crystals geometric requirements

The supramolecular synthon concept combines the chemical elements of molecular recognition with the geometrical requirements of crystal packing. The seminal 1995 review paper of Desiraju introduced the formal Hterature definition of the supramolecular synthon, based on analogy with Corey s definition of synthons for covalent synthesis. The explicit link between eovalent synthesis and crystal engineering is stressed by this analogy, and co-erystal or... 

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