Covalent bonds alkylating agents

P. Hany, E. M. Genies, C. Santier, Polyanilines with covalently bonded alkyl sulfonates as doping agent - Synthesis and properties, Synthetic Metals 1989, 31, 369. 

Amine—borane adducts have the general formula R3N BX where R = H, alkyl, etc, and X = alkyl, H, halogen, etc. These compounds, characterized by a coordinate covalent bond between boron and nitrogen, form a class of reducing agents having a broad spectmm of reduction potentials (5). 

Alkylating agent, a reactive chemical that forms a covalent bond with chemical moieties on the biological target (usually a protein). For instance, p-haloalkylamines generate an aziridinium ion in aqueous base that inserts into -SH, -CHOH, or other chemical structures in peptides. Once inserted, the effects of the alkylating agent are irreversible. 

Anticancer dtugs can be grouped into several classes, according to their mechanism of action and origin [1]. These are (i) alkylating agents and related compounds which act by forming covalent bonds with cellular... 

By definition, alkylating agents are compounds that are capable of introducing alkyl groups into nucleophilic sites on other molecules through the formation of covalent bonds. These nucleophiUc targets for alkylation include the sulfhydryl, amino, phosphate, hydroxyl. 

Cross-linkage. Bifunctional alkylating agents, such as the nitrogen mustards, may form covalent bonds with each of two adjacent guanine residues. Such interstrand cross-linkages will inhibit DNA replication and transcription. Intrastrand cross-links also may be produced between DNA and a nearby protein. 

---