Coupling synthetic methodology derivation

Synthetic Methodology Derived from the DoM-Cross-Coupling Nexus 11071... 

Synthetic Methodology Derived from the DoM-Cross-Coupling Nexus 1081 Table 14.8 One-pot DoM-Suzuki-Miyaura cross-coupling reaction to Pyr-Ar systems [25a],... 

Compared to the heterocycles described thus far, quinazolines, quinazolinones, and quinazolindiones are relatively unfamiliar and less prevalent in the literature. However, synthetic methodologies incorporating key C—N bond formations have been reported. Intermolecular C—N bond formation coupled with an intramolecular cyclization and/or condensation step has proved to be the dominant strategy, and the key substrates are o-haloarylamides or esters and their derivatives. 

New synthetic methods are the lifeblood of organic chemistry. Synthetic efforts toward natural products often provide the impetus for the development of novel methodology. Reactive synthons derived from 1,3-dioxanes have proven to be valuable intermediates for both syn- and anfz-1,3-diols found in many complex natural products. Coupling reactions at the 4-position of 1,3-dioxanes exploit anomeric effects to generate syu-1,3-diols (cyanohydrin acetonides), autz-1,3-diols (4-acetoxy-1,3-dioxanes), and either syn- or azztz-1,3-diols (4-lithio-1,3-dioxanes). In the future, as biologically active polyol-containing natural products continue to be discovered, the methods described above should see much use. 

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