Countermeasures CounterACT program

Development and validation of in vitro and/or in vivo animal models for rapid screening of molecular hbraries to identify potential medical countermeasures is another priority of the CounterACT program. These models include seizures in small mammals, models of direct lung injury from an inhaled source, animal models of cyanide intoxication, and medium throughput models of dermal or ocular injuries. It is important that models be amenable to use under GLP methodology so that the data generated are acceptable to the FDA. Since adherence to GLP standards may be expensive, earher screens to identify potential hits are usually performed under non-GLP conditions. 

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