Coumarin bioactive structures

Coumarins, The Bioactive Structures with Antifungal Property... 

The third chapter, Quantitative Structure-Cytotoxicity Relationship of Bioactive Heterocycles by the Semi-empirical Molecular Orbital Method with the Concept of Absolute Hardness by Mariko Ishihara, Hiroshi Sakagami, Masami Kawase, and Noboru Motohashi, presents the relationship between the cytotoxicity (defined as 50% cytotoxic concentration) of heterocycles such as phenoxazine, 5-trifluoromethyloxazoles, O-heterocycles such as 3-formylchromone and coumarins, and vitamin K2 derivatives against some tumor cell lines and 15 chemical descriptors. The results suggest the importance of selecting the most appropriate descriptors for each cell type and compound. The review is of interest as it represents the relationship of the molecular structures with the cytotoxic activity of these heterocycles. 

Abstract Construction of chemical libraries is a useful approach to the discovery of better fluorescent materials, and several types, such as styryl dyes and cyanine dyes, have been reported. In this chapter, we focus on construction of a library of chemicals having a coumarin skeleton as the core structure. Coumarin and its derivatives are key structures in various bioactive or fluorescent molecules, and their fluorescence properties are dependent on the precise structure, including the positions of substituents. 

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