Cotton wool sign

Vitamin B12 deficiency can also cause megaloblastic anemia. White-centered hemorrhages can occur in the posterior pole, and disc pallor also may be seen. If the anemia is severe, cotton-wool spots may appear. A complete blood count can confirm that megaloblastic anemia exists. Serum folate and vitamin B12 levels should be determined and appropriate therapy (intramuscular injections of hydroxocobalamin) should be instituted at the earliest sign of megaloblastic anemia. 

Passive soii burial tests simply involve burying fibers or textiles in soil for some period of time and then examining them for signs of biodegradation. Peacock 1431 used this method to study the changes in linen, cotton, silk and wool over a 32-week incubation time. Modelli et al. (181 buried flax fibers in soil amended with ammonium phosphate to provide inorganic nutrients and CO2 production was used to monitor the biodegradation of these fibers. 

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