Cosolvents liquid dosage forms

EXAMPLES OF THE USE OF COSOLVENTS FOR THE FORMULATION OF LIQUID DOSAGE FORMS... 

Suspensions are two-phase systems consisting of a finely divided solid dispersed in a liquid, solid, or a gas (Table 6). They are appropriate when the drug to be incorporated is not sufficiently soluble in an ordinary solvent or cosolvent system. They are used orally and topically. Examples of compounded suspensions include pediatric oral liquids where a commercial pediatric dosage form is not available. Commercial tablets and capsules are formulated into a vehicle and can be individually flavored to the patient s preference. 

If the dosage form contains cosolvents (or if, for any reason, it may be expected to extract greater amounts of substances from plastic packaging components than water), then additional extractable information may be needed to address safety issues. Performance is typically not a factor for liquid-based oral drug products. 

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