Cory palmine

Z-canadine (XXVI) there is simultaneously produced d-corypalmine, m.p. 234-5°. Similarly in the preparation of 1-tetrahydrocolumbamine from Z-canadine, Z-corypalmine, m.p. 235-7°, is also obtained. dZ-Cory-palmine obtained by crystallising an equimolecular mixture of the two forms, has m.p. 215-7°, alone or mixed with dZ-tetrahydrojatrorrhizine from calumba roots. Though d-corypalmine was the form first described the Z- and dZ- forms also occur naturally (see items quoted above). These facts establish formula (XXV =. OH Ri = R = = OMe) for... 

In study of Corydalis incisa cultivated in North America, Manske reported the presence of five alkaloids, protopine, bicuculline, cory-palmine, and an alkaloid of unknown structure designated as alkaloid F62 17). 

The mixture of the iodides are separable from the palmatine iodide by virtue of their phenolic nature and, therefore, their solubility in aqueous alkali. Jatrorrhizine generally being the major constituent it has been obtained in a satisfactory state of purity by direct crystallization of the iodide, but columbamine has only been isolated in pure form as its tetrahydro derivative. The structures of these alkaloids are discussed under cory-palmine, which is tetrahydrojatrorrhizine, and isocorypalmine, which is tetrahydrocolumbamine. 

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See also in sourсe #XX -- [ ]

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