Corticosteroids analgesic effects

CORTICOSTEROIDS ANALGESICS-NSAIDs 1. T risk of gastrointestinal ulceration and bleeding 2. Parecoxib levels may be 1 by dexamethasone 1. Additive effect 2. Dexamethasone induces CYP3A4-mediated metabolism of parecoxib 1. Watch for early signs of gastrointestinal upset remember that corticosteroids may mask these features 2. Watch for poor response to parecoxib... 

Drug interactions No formal drug interaction studies have been carried out. Clinical trials have indicated that Pulmozyme can be effectively and safely used in conjunction with standard cystic hbrosis therapies including oral, inhaled, and/or parenteral antibiotics, bronchodila-tors, enzyme supplements, vitamins, oral or inhaled corticosteroids, and analgesics. 

HA, mild pain Action Nonnarco tic analgesic w/ barbiturate Dose 1—2 tabs or caps PO q4-6h PRN i in renal/hepatic impair 4 g/24 h APAP max Caution [C, D, +] Alcoholic liver Dz Contra G6PD deficiency Disp Caps, Liq, tabs SE Drowsiness, dizziness, hangover effect Interactions T Effects OF benzodiazepines, opiate analgesics, sedatives/hypnotics, EtOH, methylphenidate hydrochloride i effects OF MAOIs, TCAs, corticosteroids, theophylline, OCPs, BBs, doxycycline EMS See Acetaminophen may impair coordination, monitor for depression concurrent EtOH use T CNS depression butalbital is habit forming... 

---