Cortical circuitry development

Englund, U., Bjorldund, A., Wictorin, K., Lindvall, O. and Kokaia, M. Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc. Natl Acad. Sci. U.S.A. 99 17089-17094,2002. 

The development of serotonergic innervation to the cerebral cortex has been characterized in neonatal rats by immunohistochemical techniques and autoradiographic imaging. These experiments demonstrate early serotonergic innervation that could be involved in a transient physiological role in sensory areas of the cortex or exert a trophic influence on the development of cortical circuitry and thalamocortical connections [76]. 

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