Cornus officinalis

Cornus officinalis Sieb. et Zucc. China Morroniside, 7-O-methyl-morroniside, sworoside, loganin, longiceroside, tannic acid, resin, tartaric acid, cornin, gallic acid, malic acid.33 60 Diuretic, treat dysmenorrhea, excessive menstruation, impotency, backache, dizziness. 

Further work on secoiridoid biosynthesis has now shown, using [7,8- H2]-7-deoxyloganic acid, that the C-8 proton as well as the C-7 proton is retained in the sequence loganin secologanin (126)— morroniside (129) (cf. Vol. 3, p. 28) in Lonicera morrowii, Cornus officinalis, and Gentiana thunbergii ... 

Ursolic acid Cornus officinalis Siebet Zucc/Cornaceae Seed Hypoglycemic activity was shown in STZ-induced diabetic rats [62],... 

C21H22O15 514.396 Constit. of Cornus officinalis. Light-tan amorph. powder + 2H2O. [a]g +0.4 (c, 0.8 in MeOH). 

Asiatic Cornelian Cherry Fruit is the dried ripe sarcocarp of Cornus officinalis Sieb. et Zucc. (Fam. Comaceae). 

Isol. from fruits of Cornus officinalis and from Tellima grandiflora. 

Isol. from Cytinus hypocistis and Cornus officinalis. Hygroscopic solid + 6H2O. 

Okuda, T., Hatano, T. Yasui, T. (1981a). Revised strucmre of isoterchebin, isolated from Cornus officinalis. Heterocycles, 16, 1681-1685. 

Okuda T, Hatano T, Yasui T 1981 Revised structure of isoterchebin isolated from Cornus officinalis. HeteroQTcles 16 1321-1325... 

Among the most common methods are those which use acidic methanol (1% HCl) as extracting solvent at room temperature [Vareed et al., 2006]. Jayaprakasam et al. (2005) used acidified water (pH = 3) to isolate anthocyanins from Cornus officinalis and Cornus mas fruits, Moldovan et al. (2014) reported the extraction of pigments from frozen Cornelian cherries in acetone while Pantelidis et al. (2007) used air dried fruits (at 55°C) and 50% aqueous methanol as solvent. In the anthocyanins extraction from Cornus alba Sibirica the plant material was extracted with methanol containing 0.2% trifluoroacetic acid [Bjoroy et al., 2007]. 

The first study of the anthocyanin content of Cornus officinalis and Cornus controversa was reported by Seeram et al. in 2002. The isolation, characterization and quantification of anthocyanins in these Cornus spp. fruits was achieved by HPLC, LC-ES/MS and NMR methods. 

The anthocyanins found in Cornus officinalis were identical to those isolated by the same authors in Cornus mas fruits delphinidin-3-O-galactoside, cyanidin-3-O-galactoside and pelargonidin-3-O-galactoside but differ in their concentrations. 

Morroniside was found to be the major irridoid in Cornus officinalis fruits. Du et al. (2008) reported a content ranging from 12.58 to 17.07 mg/g dry fruit. In contrast, other researchers identified comuside as the major constituent of the total extract of Cornus officinalis fruits, representing 26.8% of the extract [Jiang et al, 2011]. 

Recent researches led to isolation and characterization of two new iridoid glucosides loganin derivatives logmalieids A and B as well as to the first report of loganic acid and secoxyloganin in Cornus officinalis fruits [Ma et al., 2014],... 

Loganin, sweroside and morroniside, the major iridoid components in Cornus officinalis fruits, do not show a potent radical scavenging activity as compared to comuside. Loganin and comuside showed a signifieant inhibitory effect on melanogenesis in mouse melanoma cell line [Nawa et al., 2007]. 

Total triterpenic acids isolated from Cornus officinalis fruits ameliorate diabetic cardiomyopathy in streptozocin-injected rats, by suppressing the endothelin reactive oxidative species pathway in the myocardium [Qi et al., 2008]. 

Hassanpour, S, Maheri-Sis, N, Eshratkhah, B, Mehmandar, FB. Plants and secondary metabolites (tannins) A review. Int. J. Forest, Soil Erosion, 2011, 1, 47-53 Hasegawa, GR. Quinine Subtitutes in the Confederate Army. Mil. Med., 2007, 172, 650-655 Hatano, T, Ogawa, N, Kira, R, Yasuhara, T, Okuda, T. Tannins of Comaceous plants. 1. Comusiins A, B and C, dimeric, monomeric and trimeric hydrolysable tannins from Cornus officinalis, and orientation of valoneoyl group in related tannins. Chem. Pharm. Bull, 1989a, 37, 2083-2090... 

Hatano, T, Yasuhara, T, Abe, R, Okuda, T. A galloylated monoterpene glucoside and a dimeric hydrolysable tannin from Cornus officinalis. Phytochemistry, 1990, 29, 2975-2978... 

Jang, S-E, Jeong, J-J, Hyam, SR, Han, MJ, Kim, D-H. Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 on macrophages. J. Agric. Food Chem., 2014, 62, 9711-9721... 

Kang, DG, Moon, MK, Li, AS, Kwon, TO, Kim, JS, Li, HS. Comuside suppresses cytokine-induced pro-inflammatory and adhesion molecules in the human umbilical vein endothelial cells. Biol. Pharm. Bull., 2007, 30,1796-1799 Kassi, E, Papoutzi, Z, Aligianis, S, Manoussakis, M, Moutsatsou, P. Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cell line. J. Cancer Res. Clin. Oncol., 2007, 133, 493-500 Kean, KD, Hwan, KJ. A fman derivative from Cornus officinalis. Arch. Pharmacol. Res.,... 

Kim, DK, Kwak, JAH. A fiiran derivative from Cornus officinalis. Arch. Pharm. Res., 1998,... 

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