Cornea verticillata

CORNEAL SroE EFFECTS OF SYSTEMIC MEDICATIONS The cornea, conjunctiva, and even eyelids can be affected by systemic medications. One common drug deposit foimd in the cornea is from the cardiac medication amiodarone. It deposits in the inferior and central cornea in a whorl-like pattern termed cornea verticillata. It appears as fine tan or brown pigment in the epithelium that seldom affects vision and rarely causes discontinuation. The deposits disappear slowly if the medication is stopped. Other medications can cause a similar pattern, including indomethacin, atovaquone, chloroquine, and hydroxychloroquine. 

Sensory systems Cornea verticillata has been studied in 22 patients with Fabry disease and in 11 patients taking amiodarone, comparing the corneal microstructure in both types [34 ]. Confocal laser-scanning... 

Falke K, Buttner A, Schittkowski M, Stacks O, Kraak R, Zhivov A, Rolfs A, Guthoff R. The microstructure of cornea verticillata in Fabry disease and amiodarone-induced keratopathy a confocal laser-scanning microscopy study. Graefes Arch Chn Exp Ophthalmol 2009 247 523-34. 

Histopathologic findings of cornea verticillata in a woman heterozygous for Fabry s disease. Cornea... 

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