Cornea classification

Several in vitro methods, including the hen s egg chorioallantoic membrane test (HET-CAM) the bovine cornea opacity and permeability assay (BCOP) and the isolated rabbit eye (IRE) test, have gained regulatory acceptance in Europe for the classification of severe eye irritants. Many companies are using such techniques successfully to reduce in vivo testing during development. ... 

There are major key issues on stem cells that explain poor prognosis of Grade HI bums including ischemia of the limbus to an extent of more than 50%, according to the classification of Reim [45]. The overall concept of stem cell survival on the cornea was pubhshed by Tseng [46]. This concept gives a clear insight that survival of stem cells is cmcial for successful comeal reepithehalization. 

Holland, J.H., Schwartz, G.S. The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea 15, 549-556 (1996)... 

Slit-lamp evaluation, with particular attention to the cornea, anterior chamber depth, and an estimation of the anterior chamber angle by shadow test or van Herick s classification... 

Table 2. Classification and criteria for evaluation of fluorescein staining of the cornea... 

The eyes were assessed by awarding scores at certain intervals after apphca-tion under the Draize scheme. The 24/48/72-hour mean scores were determined for the cornea, for conjunctiva, and for the iris. All responses were checked for reversibihty for 21 days. The results are given in Table 19. alkyl polyglycoside does not have to be classified as a hazard or labeled as such [101], whereas alkyl polyglycosides fall within the R36 ( irritating to the eyes ) category of the E.U. risk classification [102]. 

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