Coptisine coreximine

Corydalis incisa (Thunb.) Pers. C. bungeana Turcz. Chuan Duan Chang Cao Di Ding Zi Jing (Corydalis) (whole plant) Protopine, pallidine, sinocecatine, corynoline, isocorynoline, coptisine, corycavine, acetylcorynoline, corynoloxin, coreximine, reliculine, corydamine, scoulerine.33,50 For rectal prolapse, abscesses, hemorrhoids. 

Canadine, canadine methohydroxide, cheilanthifoline, coreximine, isocorypalmine (= tetrahydrocolumbamine), scouierine, sinactine, stepholidine, stylopine, P-stylopine methohydroxide berberine, coptisine, corysamine, palmatine... 

There are numerous protoberberine- and tetrahydroprotoberberine-type alkaloids including berberine (9), coptisine, scoulerine, isocorypalmine and coreximine. Berberine contracts uterine muscle and has been used to stop uterine bleeding and to help in childbirth. Its action is relatively weak and uncertain and because it has somewhat toxic properties it is no longer used for these purposes. Berberine also exerts some antiinflammatory activity (Otsuka et al. 1981) and it does depress the formation of connective tissue. When berberine is infused in a dose of 0.2 mg kg it has a positive inotropic effect on dog heart, reducing heart rate and decreasing total peripheral resistance of blood circulation (Maroko et al. 1982). (—)-Coreximine (10), also found in opium, is closely related to berberine and it also acts with a positive inotropic effect on dog heart and reduces heart rate when it is infused with 0.2 mg kg . Coptisine (11) has an inhibitory effect on the formation of connective tissue (Otsuka et al. 1981). 

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