Quinoproteins copper

From the sequence of reactions found it follows that copper-quinoprotein amine oxidases catalyze an aminotransferase reaction. A different reaction sequence occurs with flavoprotein amine oxidases (EC 1.4.3.4), where formation of NH3 is not dependent on the presence of 02. However, since reductive trapping of amines in the first half-reaction [86] showed attachment of substrate but not of tritium, the mechanism is also different from the aminotransferase reaction that... 

Cu has a bifunctional role in copper-quinoprotein amine oxidases, catalyzing the formation of TPQ from the specific tyrosy l residue in the precursor protein and playing a role in the catalytic mechanism, most probably with 02 reacting with Cu(I) in the oxidative part of the cycle. The recent discovery of LTQ suggests that other combinations of quinone cofactors may be found in the future. 

J. V. lersel, R. A. van der Meer, and J. A. Duine, Methylamine oxidase from Athrobacter FI, a bacterial copper-quinoprotein amine oxidase, Eur. ]. Bio-chem., 161 415 (1986). 

Mclntire, W. S., and Hartmann, C., 1993, Copper-containing amine oxidases in Principles and Applications of Quinoproteins, Editor Davison, V., Marcel Dekker publisher 97fi 171. 

W. S. Mclntire C. Hartmann, Copper-Containing Amine Oxidases. In Principles and Applications of Quinoproteins ... 

Hacisalihoglu, A., Jongejan, A., Jongejan, J. A., and Durne, J. A., "Enantioselective oxidation of amphetamine by copper-containing quinoprotein amine oxidases from Escherichia coli and Klebsiella oxytoca.". Mol. Catal. B Enzym., 11,81-88 (2000). 

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