Copper , imine-oxime complexes

Interest is mounting in this state, promoted once again by its possible implication in biological systems. Galactose oxidase, for example, is a copper enzyme which catalyses the oxidation of galactose to the corresponding aldehyde. The tervalent oxidation state may be prepared from Cu(II) by chemical, anodic and radical oxidation. Cu(III) complexes of peptides and macrocycles have been most studied, particularly from a mechanistic viewpoint. The oxidation of I" by Cu(III)-deprotonated peptide complexes and by imine-oxime complexes have a similar rate law... 

Considerable work has been published on 2-pyridine oximes (16) which can be considered as imine oximes in which the imine fragment is a part of a heteroatomic ring. For example, Cu(II) complexes of (17 R = Ph or Me) have shown a subnormal magnetic moment of 1.0 BM and their EPR spectra suggest a strong coupling between the copper atoms. 

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