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Copper hydride alkyl halides

Scheme 5.7 illustrates these and other applications of the hydride donors. Entries 1 and 2 are examples of reduction of alkyl halides, whereas Entry 3 shows removal of an aromatic halogen. Entries 4 to 6 are sulfonate displacements, with the last example using a copper hydride reagent. Entry 7 is an epoxide ring opening. Entries 8 and 9 illustrate the difference in ease of reduction of alkynes with and without hydroxy participation. [Pg.425]

Reactions.—New systems for the reduction of alkyl halides to alkanes include mixtures of lithium aluminium hydride with transition-metal chlorides (such as Ni or Co" chlorides) and some complex metal hydrides of copper, especially the THF-soluble Li4CuHs. Details of the application of sodium cyanoborohydride to the reduction of halides (and sulphonate esters) in dipolar aprotic solvents have been published. Virtually all other functional groups are inert to this convenient, mild, and efficient system, which has been used to develop a one-pot deoxygenation of primary alcohols (Scheme 39) via the iodides. The alternative cyanoborohydride reagents (55) and the polymeric (56) are also discussed. ... [Pg.130]

See other pages where Copper hydride alkyl halides is mentioned: [Pg.274]    [Pg.6]    [Pg.801]    [Pg.571]    [Pg.337]    [Pg.398]    [Pg.347]    [Pg.398]    [Pg.14]    [Pg.130]    [Pg.201]    [Pg.248]    [Pg.282]    [Pg.110]    [Pg.142]    [Pg.295]    [Pg.295]    [Pg.313]    [Pg.333]    [Pg.348]    [Pg.383]    [Pg.384]    [Pg.388]    [Pg.542]    [Pg.543]    [Pg.693]    [Pg.712]    [Pg.772]    [Pg.776]    [Pg.267]    [Pg.16]    [Pg.240]    [Pg.221]    [Pg.20]    [Pg.348]   
See also in sourсe #XX -- [ Pg.801 ]



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Copper alkyls

Copper halides

Copper hydrides

Hydride halides

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