Salicylic acid copper complexes

To evaluate the time-course of analgesia associated with a non-steroidal anti-inflammatory agent and its copper complex, salicylic acid and its complex were compared in the polyarthritis pain model following oral administration in 5 % gum arabic. Data presented in Figure 6.4 show that analgesic activity increased in a dose-related manner and that Cu(II))(salicylate)2 was 7- to... 

Copper complexes were used as efficient catalysts for selective autoxidations of flavonols (HFLA) to the corresponding o-benzoyl salicylic acid (o-BSH) and CO in non-aqueous solvents and at elevated temperatures (124-128). The oxidative cleavage of the pyrazone ring is also catalyzed by some cobalt complexes (129-131). 

Terminally metallizable dyes (30) are obtained by the interaction of a diazonium salt and a coupling component containing a chelating system, for example salicylic acid, catechol, salicyl-aldoxime or 8-hydroxyquinoline, and their coordination chemistry is typical of these compounds. Such dyes were rarely used as preformed metal complexes but were usually applied to cotton and then converted to their copper complexes on the fibre to improve their fastness to wet treatments. A typical example is the blue dyestuff (31). 

Copper complexes (152) of o-hydroxy-o -(p-aminoethylamino)diarylazo compounds have been prepared ° by the reaction of the corresponding o-chloro-o -hydroxydiarylazo compounds and ethylenediamine in the presence of copper(II) ions (c/. Section 58.2.3. l(iii)(c)). Dyestuffs of this type have been evaluated on nylon but are reported to have very poor fastness properties. Copper complexes such as (153) have been preparedby similar methods. Other, related tetradentate diarylazo compounds, e.g. (154), (155) and (156), are obtained by the reaction of a suitable diazonium salt with the appropriate diarylamine. Chromium(III) and cobalt(III) complexes of dyes of this type, in which the coordination sphere of the metal is completed by a colourless bidentate ligand such as ethylenediamine, salicylic acid or 8-hydroxyquinoline, are reported to have dyeing properties on wool similar to those of the comparably charged 2 1 complexes derived from tri-... 

Another spectrophotometric determination of salicylic acid in pharmaceutical formulations using copper acetate as a color developer. Different vol. of salicylic acid solution (10 mg/ml) were mixed with an equal vol. of copper acetate solution and made up to 10 ml with Na acetate acetic acid buffer (pH 5.6 to 6.0). The absorbance of the stable, yellowish-green complex was measured within 30 h at 730 nm (24). 

Bolm and coworkers developed a chiral copper complex from an oxazoline and salicylic acid for the Baeyer-Villiger oxidation employing oxygen and an aldehyde for the oxidant, and high ee was obtained with a 4-nitro-6-(f-butyl)salicylic acid derivative (equation Salicylaldehyde itself can be used as a catalyst ligand for the... 

The list of compounds presented in Table 6.4 includes copper complexes of well-known antiarthritic drugs, including salicylic acid, aspirin, diflunisal, niflumic acid, D-penicillamine, hydrocortisone, dexamethasone, dimethyl-sul-phoxide, clopirac, ketoprofen, ibuprofen, (+ )-naproxen, indomethacin, me-fenamic acid, thiomalic acid, phenylbutazone, lonazolac, isoxicam and azo-propazone. While there has been much discussion concerning the qualitative and quantitative activities of these complexes [136, 152-156, 164, 187], it is... 

More recent studies have clearly shown that Cu(II)(anthranilate)2, Cu(II)(salicylate)2, Cu(II)2(3,5-DIPS)4, Cu(II)2(aspirinate)4, Cu(II)2(niflu-mate)4, and Cu(II)2(indomethacin)4 are more effective analgesics than their parent ligands [93]. As shown in Table 6.5, copper complexes of salicylic acid,... 

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