Cooperative Thyrotoxicosis Therapy

Dobyns BM, Sheline GE, Workman JB, Tompkins EA, McConahey WM, Becker DV. Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism a report of the cooperative thyrotoxicosis therapy follow-up study. J Clin Endocrinol Metab 1974 38(6) 976-98. 

The Cooperative Thyrotoxicosis Therapy Follow-up Study showed that long-term thyroid problems occur in children treated with lower, rather than higher, doses of Thyroid adenomas developed in 30% of 30 children treated in one center with low doses of estimated to result in thyroid exposure of 25 Gy [33,50]. Yet, when children were treated with higher doses of (100-200 Gy), the incidence of thyroid neoplasms did not increase (Dobyns etal, 1974). 

The treatment of type 1 AIT is more difficult than that of other forms of iodine-induced thyrotoxicosis. Discontinuation of amiodarone therapy is usually recommended in patients with type 1 AIT, as long as other anti-arrhythmic drugs are available. However, withdrawal of amiodarone is often difficult because of underlying severe heart disease. High doses of antithyroid drugs have been used to treat type 1 AIT. Combined therapy with antithyroid drugs and potassium perchlorate is recommended in patients who fail to respond to antithyroid drugs alone after 2—3 months of treatment (Basaria and Cooper,... 

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