Convulsions system dysfunction seizures

Sedation is uncommon and instead many patients will find that these drugs may impair sleep, which is why the dose is best taken in the morning. There is also little effect on psychomotor function. Occasional patients have a small reduction in heart rate but otherwise effects on the cardiovascular system are rare. Epileptic convulsions can occur but are rare and much less common than with tricyclic antidepressants. There is some evidence for potentiation of electroconvulsive therapy (ECT)-induced seizures. Sexual dysfunction is reported, principally delayed ejaculation and anorgasmia. 

Considerable evidence, particularly in the last five years, has spotlighted PC as a key seizurogenic site in the cerebral cortex and dysfunction of this area may play an important role in temporal lobe epilepsy. Systemic injection of muscarinic receptor agonists or acetylcholinesterase inhibitors produces robust, sustained seizure activity in PC. Several recent studies have demonstrated that PC is the first cortical or subcortical forebrain structure to exhibit increased c-fos expression, a marker for elevated neuronal activity, after convulsive doses of pilocarpine or the irreversible acetylcholinesterase... 

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