Convulsions antipsychotics causing

Toxicology LD50 (oral, rat) 23,160 mg/kg, (IP, rat) > 1 g/kg, (IV, mouse) 1530 mg/kg harmful by inh., skin contact danger of cumulative effects may cause somnolence, muscle weakness, ataxia, convulsions, antipsychotic behavior, changes in liver/kidney/spleen wt. suspected carcinogen tumorigen mutagen TSCA listed... 

Mesoridazine, a metabolite of thioridazine, is thought to exert its antipsychotic effects by postsynaptic blockade of CNS dopamine receptors, thereby inhibiting dopamine-mediated effects. Mesoridazine has many other central and peripheral affects it produces both alpha and ganglionic blockade and counteracts histamine- and serotonin-mediated activities. Mesoridazine and thioridazine cause fewer movement disorders (see Phenotheazine Derivatives). Mesoridazine is metabolized to inactive metabolites, which are excreted by the kidneys. Overdosage of mesoridazine causes CNS depression characterized by deep, unarousable sleep, convulsive seizures, and cardiac arrhythmias (see also Table 2). 

Central nervous system (CNS) depressants such e alcohol, narcotic analgeie, tricyclic antidepresants (see Cliap. 31), and the antipsychotic dru (see (Dli i. 32), increase the sedative effects of the antianxiety dru. Combination of any of th se dru with the antianxiely dni is dangerous and can cause serious respiratory depression and profound sedation. Ingestion of alcohol with the antianxiely dru can cause convulsions and coma... 

Overdosage toxidty Poisoning with antipsychotics other than thioridazine is not usually fatal. Hypotension often responds to fluid replacement. Neuroleptics lower the convulsive threshold and may cause seizures, which are usually managed with diazepam or phenytoin. Thioridazine overdose, because of cardiotoxicity, is more difficult to treat. 

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