Convergent strategy peptides

The synthesis and isolation of many of these receptors proved to be quite tedious, however, although occasionally convergent strategies could be used. We therefore looked for an alternative way to build up such structures and decided to make use of self-assembly processes of metal complexes [4] to build up self assembled oligo(BINOL) analogs [5], (How similar metal complexes can be used to stabilize peptide microstructures is discussed in Chapter 1.3.)... 

Watt GM, Boons GJ. A convergent strategy for the preparation 43. of N-glycan core di-, tri-, and pentasaccharide thioaldoses for the site-specific glycosylation of peptides and proteins bearing free 44. cysteines. Carbohydr Res. 2004 339 181-193. 

Other convergent strategies for the synthesis of peptides are based on the solid-phase synthesis of unprotected or of minimally protected peptide fragments and their coupling in solution by chemical rneansf " or by using enzymes. ... 

Examples of convergent strategies for the synthesis of O-Glycopeptides have been reported, where the serine or threonine hydroxyl is used as a glycosyl acceptor [40]. These methods require extensive protection of the peptide and carbohydrate. Other pitfalls in this strategy... 

Tetrameric Peptide Synthesis by Convergent Strategy (Scheme 18.1)... 

Solution-phase synthesis, the synthesis of peptides in solution. Despite the dominance of solid-phase peptide synthesis (SPPS), solution-phase synthesis still is of importance for the synthesis of peptides on a larger scale, including the preparation of peptide pharmaceuticals. Peptide synthesis in solution may foUow either linear or convergent strategies. The linear synthesis is mostly employed for small peptides and peptide segments... 

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